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Filtered Search Results
Apexbio Technology LLC Apixaban 503612-47-3 200mg
Apixaban (CAS 503612-47-3) is a highly selective reversible inhibitor of coagulation Factor Xa with Ki values of 0 08 nM and 0 17 nM for human and rabbit enzymes respectively By targeting Factor Xa a central serine protease in the coagulation cascade apixaban effectively impedes thrombin generation and subsequent clot formation In vitro apixaban prolongs coagulation parameters in human plasma at submicromolar concentrations and demonstrates potent antithrombotic activity across multiple animal models With favorable pharmacokinetics including high oral bioavailability and low clearance in preclinical studies apixaban serves as a valuable tool for investigating coagulation mechanisms and evaluating anticoagulant strategies
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Aobchem 2 4-Dimethylthiophene-3-carbaldehyde | ≥97% | CAS 63826-85-7 | C7H8OS | 1g
2 4-Dimethylthiophene-3-carbaldehyde | ≥97% | CAS 63826-85-7 | C7H8OS | 1g
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Aobchem 3 4-Dimethoxythiophene-2-carboxylic acid | ≥97% | CAS 113589-62-1 | C7H8O4S | 500mg
3 4-Dimethoxythiophene-2-carboxylic acid | ≥97% | CAS 113589-62-1 | C7H8O4S | 500mg
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Apexbio Technology LLC GSK1070916 942918-07-2 200mg
GSK1070916 (CAS 942918-07-2) is a selective ATP-competitive inhibitor targeting Aurora kinase B and C displaying Ki values of 0 38 nM and 1 5 nM respectively The compound demonstrates marked selectivity over Aurora kinase A with IC50 values of approximately 5 nM (Aurora B) versus 1259 nM (Aurora A) In vitro studies show that GSK1070916 inhibits proliferation of human lung cancer cells (A549) with an EC50 of roughly 7 nM Additionally the compound effectively reduces phosphorylation of histone H3 an Aurora B substrate and exhibits tumor growth inhibition in HL-60 xenograft mouse models GSK1070916 is utilized in tumor biology research investigating Aurora kinase signaling pathways
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Medchemexpress LLC Lificiguat | 170632-47-0 | 99.7% | 304.34 | 200 MG
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Lificiguat (YC-1) is a soluble guanylyl cyclase (sGC) activator that binds to the β subunit of sGC. It stimulates sGC activity, especially in the presence of CO or NO, leading to several hundred-fold activation. This compound has also been shown to inhibit tumor growth and improve rodent learning behavior.
- Binds to the β subunit of soluble guanylyl cyclase (sGC)
- Activates sGC, synergistically with carbon monoxide or nitric oxide
- Inhibits tumor growth
- Improves rodent learning behavior
- Enhances long-term potentiation (LTP)
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Medchemexpress LLC TMP269 | 1314890-29-3 | 98.2% | 514.52 | 200 MG
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TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor, targeting HDAC4, HDAC5, HDAC7, and HDAC9. It is intended for research use only. TMP269 modulates cell cycle progression and enhances cytotoxicity in certain cell lines, without affecting class I or IIb HDACs. It has also shown antiangiogenic effects in vivo.
- Novel and selective class IIa histone deacetylase (HDAC) inhibitor
- Targets HDAC4, HDAC5, HDAC7, and HDAC9
- Modulates cell cycle progression in IEC-18 intestinal epithelial cells
- Enhances CFZ-induced cytotoxicity in MM cell lines
- No inhibitory effects on class I or IIb HDACs
- Demonstrates antiangiogenic effects in vivo
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Medchemexpress LLC Firmonertinib mesylate | 2130958-55-1 | 99.9% | 664.70 | 25 MG
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Firmonertinib mesylate is an orally active, mutant-selective, and blood-brain barrier penetrant EGFR inhibitor. It inhibits EGFR active mutations and the T790M acquired resistant mutation. This compound has potential for research into cancer diseases, particularly advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation.
- Orally active
- Mutant-selective
- Blood-brain barrier penetrant EGFR inhibitor
- Inhibits EGFR active mutations
- Inhibits T790M acquired resistant mutation
- Potential for research of cancer diseases, especially advanced non-small cell lung cancer (NSCLC) with EGFR ex20ins mutation
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Medchemexpress LLC Trovafloxacin mesylate | 147059-75-4 | MFCD00913361 | 99.8% | 512.46 g/mol | C21H19F3N4O6S | 1 ML
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Trovafloxacin mesylate is the mesylate salt of trovafloxacin, a broad-spectrum fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV. It is used in research to study antibacterial activity and pannexin 1 (PANX1) channel function and inhibition.
- Broad-spectrum fluoroquinolone antibiotic that inhibits DNA gyrase and topoisomerase IV.
- Also reported as a pannexin 1 (PANX1) inhibitor with an IC50 around 4 μM.
- Available as a 10 mM solution in DMSO (1 mL) and as solid quantities for experimental flexibility.
- High purity: 99.8% (HPLC) as reported by supplier.
- CAS number 147059-75-4; molecular weight 512.46 g/mol.
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Medchemexpress LLC Bromocriptine mesylate | 22260-51-1 | MFCD00069218 | 100.0% | 750.70 g/mol | C33H44BrN5O8S | 5 MG
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Bromocriptine mesylate is the methanesulfonate salt of bromocriptine, a semisynthetic ergot-derived dopamine D2/D3 receptor agonist used in research. It shows high affinity for D2 receptors (pKi ≈ 8.05) and is provided as both a solid and solution format for laboratory and analytical applications.
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Medchemexpress LLC Deferoxamine mesylate (standard) | 138-14-7 | 99.47% | 50 MG
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Deferoxamine mesylate (Standard) is an analytical standard intended for research and analytical applications. It functions as an iron chelator, binding to Fe(III) and other metal cations, thereby reducing iron accumulation and deposition in tissues. This compound also upregulates HIF-1α levels and exhibits good antioxidant activity, along with anti-proliferative activity that can induce apoptosis and autophagy in cancer cells.
- Used in studies related to diabetes, neurodegenerative diseases, anti-cancer research, and anti-COVID-19 research
- Serves as a reference standard for assays
- Frequently utilized in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS
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Medchemexpress LLC Ruboxistaurin mesylate | 192050-59-2 | MFCD09970504 | 99.9% | 564.65 | C29H32N4O6S | 5 MG
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Ruboxistaurin mesylate is an orally active, ATP-competitive, and selective protein kinase C beta (PKCβ) inhibitor used in preclinical research on diabetic complications, retinal/eye disorders, and cardiovascular disease. It is supplied as a solid with high reported purity and is soluble in DMSO for in vitro applications.
- Selective PKCβ inhibitor with low-nanomolar potency.
- Orally active small molecule suitable for in vitro and in vivo studies.
- High reported purity (~99.9%) for research applications.
- Solid form, orange to red color, easy handling and storage.
- Soluble in DMSO at 50 MG/ML (88.55 mM); ultrasonic assistance may be required.
- Storage guidance: 4°C sealed; in solvent: -80°C (6 months), -20°C (1 month).
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TARGETMOL CHEMICALS INC KB-R7943 MESYLATE 25MG
Also available in 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. KB-R7943 mesylate is a widely used inhibitor of the reverse Na+/Ca2+ exchanger (NCXrev) with IC50 of 5.7±2.1 uM. purity: 99%
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Medchemexpress LLC Danofloxacin mesylate | 119478-55-6 | 99.88% | 1 G
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Danofloxacin mesylate (CP 76136-27) is a fluoroquinolone veterinary drug with broad-spectrum bactericidal activity. It primarily inhibits the DNA gyrase of bacteria and is a substrate for ATP-dependent efflux transporters (P-gp and MRP2). It is designed for laboratory research.
- Fluoroquinolone veterinary drug
- Broad-spectrum bactericidal activity
- Inhibits bacterial DNA gyrase
- Substrate for ATP-dependent efflux transporters (P-gp and MRP2)
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TARGETMOL CHEMICALS INC SAFINAMIDE MESYLATE 25MG
Also available in 2 mg 5 mg 10 mg 50 mg 100 mg 1 mL 10 mM (in DMSO) and bulk. Please contact Fisher for quotes. Safinamide mesylate (EMD 1195686 mesylate) a mesylate salt of Safinamide can reversibly and specifically inhibit MAO-B (IC50 98 nM) has 5918-fold selectivity against MAO-A. purity: 98%
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Medchemexpress LLC Dihydroergotamine mesylate | 6190-39-2 | 99.94% | 50 MG
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Dihydroergotamine mesylate is a BBB-permeable ergot alkaloid for the research of migraines. It reduces cell survival in A549 and NCI-H226 cells and inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells.
- Reduces cell survival in A549 and NCI-H226 cells
- Inhibits cell survival in Hep3B, PLC/PRF/5, Huh7, and HepG2 cells
- Induces mitochondrial morphologic alterations and dysfunction
- Increases ROS generation and induces apoptosis
- Disturbs ATP production in A549 cells
- Inhibits STAT3 activation and enhances protein stability of Mcl-1
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